Health News: Scientists develop diabetes drug to replace insulin injections

The word diabetes written

Diabetic patients might no longer be injected with insulin but will start taking pills to treat their condition, so stated by a group of Australian Researchers.

Research led by the University of Adelaide is testing safer and more effective drugs to treat type-2 diabetes which will reduce side-effects and insulin injections.

According to the two studies which was published in the Journal of Medicinal Chemistry and BBA-General Subjection,  it was revealed that the two new drugs could be more efficient in reducing blood sugar.

One of the main reasons that triggered this research was the unsafe and ineffective usage of insulin injections.
The two new drugs work by targeting a protein receptor known as PPARgamma found in fat tissue throughout the body to lower blood sugar by increasing sensitivity to insulin and changing the metabolism of fat and sugar.

The first study, undertaken in partnership with The Scripps Research Institute in the US, described 14 versions of a drug which worked by partially activating PPARgamma, an outcome which resulted in fewer side effects than full activation.

The second study which was in collaboration with South Australia's Flinders University, used X-ray crystallography to demonstrate how a drug, rivoglitazone, binds with the PPARgamma receptor. Rivoglitazone fully activates PPARgamma but produced fewer side effects than other drugs that activate the same way.

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Incase you are not much enlightened on this disease, type-2 diabetes is characterized by a resistance to insulin and subsequent high blood sugar, usually resulting from lifestyle factors like poor diet and lack of exercise.

According to John Bruning from the University's School of Biological Sciences and Institute for Photonics and Advanced Sensing, developing safer and more efficient drugs is essential. He further stated that "prevalence of type two diabetes in Australia alone has more than tripled since 1990, with an estimated cost of 6 billion AU dollars ($4.5 billion) a year."

Bruning said injecting insulin is problematic, and it is "highly desirable" for people to come off the injections as it's difficult to get the levels right.

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